Herbal Buccal Patches with Enhanced Bioavailability and Mucosal Retention for Oral Ulcer Treatment

Resumen

The present study aimed to formulate and evaluate herbal buccal patches for the management of oral ulcers using plant extracts with documented antiulcer potential. Four herbal extracts—Psidium guajava (guava), Lavandula angustifolia (lavender), Thymus vulgaris (thyme), and Matricaria chamomilla (chamomile)—were selected based on their traditional use in the treatment of gastric and mucosal disorders. The prepared buccal patches were evaluated for physicochemical characteristics, in vitro drug release, and antiulcer activity. The results demonstrated that the herbal buccal patches exhibited significant antiulcer efficacy compared to the control group. Among the tested formulations, patches containing guava and lavender extracts showed the highest therapeutic activity. Additionally, the formulations exhibited rapid drug release and enhanced immunological response, indicating improved mucosal healing potential. The findings of this study highlight the promising role of herbal buccal patches as a novel, effective, and patient-friendly therapeutic approach for the treatment of oral ulcers.