To Perform Formulation Development and Evaluation of Pantoprazole Floating Tablet by Using 23 Factorial Design

Resumen

Pantoprazole is a protein pump inhibitor (PPI) used to treat acute duodenal ulcers, acute benign gastric ulcers, gastroesophageal reflux disease (GERD), and as a preventative measure for duodenal ulcer. It has a local effect on the stomach and works by competitively inhibiting the enzyme H+/K+ ATP, which is found in the gastric parietal cells. For acute duodenal ulcers, acute benign gastric ulcers, and gastroesophageal reflux disease (GERD), the usual oral dosage recommendation is 40 mg, and it is taken for 8–12 weeks. The preparations of Pantoprazole floating tablets was attempted in the current investigation and optimize the formulation using different excipients like HPMC K4M, cyclodextrin, sodium bicarbonate, citric acid and microcrystalline cellulose were used in the direct compression method to create Pantoprazole floating tablets (250 mg).